Red Blood Cell Testing
Blaze’s current RBC fragility testing approach involves three main steps:
- Subjecting a small sample containing RBC to a controlled mechanical stress (via electromagnetic bead-milling),
- Ascertaining in real-time (via proprietary spectral analysis) the progressively increasing amount of hemolysis occurring over time at a given stress intensity, and
- Generating a 2D fragility profile (i.e. hemolysis vs. stress duration), from which one or more index values can be obtained to characterize the sample.
Additionally, a more comprehensive “3D” profile can be constructed by running multiple (sub)samples at different stress intensities – and/or varying other stress parameters, some of which can have particular relevance for specific applications. Integrated systems performing the test will employ disposable cartridges for each sample to be tested. Click here to learn more about Research Use systems.
Blaze’s proprietary spectral analysis allows RBC hemolysis to be measured in a sample without centrifugation or other separation required. In addition to facilitating the fragility test, this technology by itself can also aid with simple hemolysis testing.